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Physical and Life Sciences
LLNL-led study uses machine learning, veterans’ health records to identify ALS drug-repurposing candidate
A Lawrence Livermore National Laboratory (LLNL)-led team of scientists and computational engineers has identified several existing medications that may be associated with longer survival in people with amyotrophic lateral sclerosis (ALS), using one of the largest electronic health record datasets ever assembled for ALS. Published in The Lancet Digital Health, the study…
LLNL honors 36 as 2026 Distinguished Members of Technical Staff
Thirty-six Lawrence Livermore National Laboratory (LLNL) researchers have been named Distinguished Members of Technical Staff (DMTS) in recognition of their extraordinary scientific and technical contributions, as affirmed by their professional peers and the broader scientific community. As distinguished citizens of the Laboratory and their respective fields, DMTS honorees…
LLNL, Meta co-develop groundbreaking polymer-chemistry dataset for training AI models
Polymers are fundamental to our daily lives, serving as the core components for a wide array of goods, including clothing, packaging, transportation infrastructure, construction materials and electronics. Advances in polymer science open pathways for recycling and upcycling waste materials into more valuable chemical feedstocks. They also can have an outsized environmental…
Pathogen-agnostic testing reveals hidden respiratory threats in negative samples
The COVID-19 pandemic brought the term “Polymerase Chain Reaction testing” into the mainstream. The PCR method is a type of nucleic acid amplification test (NAAT) that detects a pathogen by finding and amplifying components of its genetic material, and it is widely used to detect SARS-CoV-2. But these types of tests have a weakness: you have to know exactly what pathogen…
Keeping the public safe at the big game: LLNL’s RAP team deploys to Santa Clara, California
As thousands of fans streamed toward Levi’s Stadium for the Super Bowl between the Seattle Seahawks and New England Patriots, vendors hawked memorabilia, the scent of garlic fries filled the air and security officers checked clear bags beneath white tents. Somewhere in that crowd, walking the same sidewalks and concourses, were a handful of team members carrying gear…
Advanced Radiographic Capability achievements featured in Physics of Plasmas
Lawrence Livermore National Laboratory’s National Ignition Facility (NIF) is the hottest place on earth for the briefest of moments during an experiment. Now, it can be one of the brightest places thanks to the Advanced Radiographic Capability (ARC), NIF’s laser-within-the-laser. How this is possible and how it’s measured is detailed in the cover paper of the December 2025…
Transistor-like membranes enhance ion separation
By applying voltage to electrically control a new “transistor” membrane, researchers at Lawrence Livermore National Laboratory (LLNL) achieved real-time tuning of ion separations — a capability previously thought impossible. The recent work, which could make precision separation processes like water treatment, drug delivery and rare earth element extraction more efficient,…
Novel directionality algorithm from student-led team selected as featured journal article
Many areas of science and engineering face the same challenge: how to infer a preferred direction when the information is spread across many measurements rather than appearing as a single clear feature. This arises in particle physics and astronomy, as well as in imaging and machine learning, whenever data take the form of a two-dimensional grid, or histogram. A student…
Advanced simulation and modeling pave a path forward for single-crystal battery materials
The performance of rechargeable batteries is governed by processes deep within their components. A fundamental understanding of electrochemistry, structure–property–performance relationships and the effects of processing and operating conditions is essential for accelerating the development of next-generation battery technologies capable of powering electric vehicles,…
Americium, curium and californium — oh my! Crystallizing the rarest elements at LLNL
Actinides are a group of heavy, radioactive elements that include uranium, plutonium, americium, curium, berkelium and californium. Understanding how these elements bond with other atoms (known as coordination chemistry), how they behave in water and how they can be separated from one another is crucial for safer nuclear waste management, new reactor technologies and…
Finding resonance: How LLNL expertise is amplifying collaboration in quantum computing
In November, the Department of Energy Office of Science renewed the Superconducting Quantum Materials and Systems Center (SQMS), hosted by Fermi National Accelerator Laboratory, with $125 million over the next five years to accelerate breakthroughs in quantum information science. The investment continues to unite more than 300 experts from 43 partner institutions across…
LLNL researchers discover new way to ‘cage’ plutonium
Plutonium (Pu) exhibits one of the most diverse and complex chemistries of any element in the periodic table. Since its discovery in 1940, scientists have synthesized and studied many different types of plutonium-containing compounds using tools that reveal both their atomic structures and how they interact with light. Not only does plutonium have numerous alloys and…
Fentanyl or phony? Machine-learning algorithm learns to pick out opioid signatures
New forms of fentanyl are created every day. For law enforcement, that poses a challenge: how do you identify a chemical you’ve never seen before? Researchers at Lawrence Livermore National Laboratory (LLNL) aim to answer that question with a machine-learning model that can distinguish opioids from other chemicals with an accuracy over 95% in a laboratory setting. The…
When lasers cross: LLNL finds a brighter way to measure plasma
Measuring conditions in volatile clouds of superheated gases known as plasmas are central to pursuing greater scientific understanding of how stars, nuclear detonations and fusion energy work. For decades, scientists have relied on a technique called Thomson scattering, which uses a single laser beam to scatter from plasma waves as a way to measure critical information…
Lab physicist receives Sylvie Jacquemot Early Career Prize
Staff scientist Elizabeth Grace of Lawrence Livermore National Laboratory (LLNL) has been awarded the 2026 European Physical Society-Plasma Physics Division (EPS-PPCF) Sylvie Jacquemot Early Career Prize. “I am very honored to receive this award,” Grace said. “I appreciate the support from my mentors and the opportunities at LLNL, which made this work possible.” She was…
Simulations and supercomputing calculate one million orbits in cislunar space
Satellites and spacecraft in the vast region between the earth and moon and just beyond — called cislunar space — are crucial for space exploration, scientific advancement and national security. But figuring out where exactly to put them into a stable orbit can be a huge, computationally expensive challenge. In an open-access database and with publicly available code,…
Nanotubes with lids mimic real biology
When water and ions move together through channels only a nanometer wide, they behave in unusual ways. In these tight spaces, water molecules line up in single file. This forces ions to shed some of the water molecules that normally surround them, leading to the unique physics of ion transport. Biological channels are especially adept at this behavior, often choreographing…
Light-based 3D printing lets scientists program plastic properties at the microscale
Researchers at Lawrence Livermore National Laboratory (LLNL) have co-developed a new way to precisely control the internal structure of common plastics during 3D printing, allowing a single printed object to seamlessly shift from rigid to flexible using only light. In a paper published today in Science, the researchers describe a technique called crystallinity regulation…
LLNL’s energy scale-up brainstorming event focused on accelerating pilot-ready technologies
Solving tomorrow’s challenges in energy security requires scientists to develop new pathways to streamline innovation. To help achieve this goal, the Global Security Directorate at Lawrence Livermore National Laboratory (LLNL) recently hosted an “Energy Scale-up Brainstorming Day.” More than 60 researchers across a broad range of expertise gathered to engage in interactive…
LLNL releases Generalized Economics Model for fusion energy
Lawrence Livermore National Laboratory (LLNL) has released a new tool designed to help the fusion energy industry assess the economic impact of plant operation and design trade-offs for building an inertial fusion energy (IFE) power plant. The Generalized Economics Model (GEM) for Fusion Technology is now available to download. “GEM helps the fusion industry understand how…
