Technology will be used at 2002 Winter Olympics
The results of the work, by researchers at Livermore and Los Alamos
national laboratories, will form part of the security network at the 2002
Winter Olympics in Salt Lake City.
"The events of Sept. 11 have demonstrated the importance of taking
the bio-threat seriously," said Gen. John Gordon, administrator of
the National Nuclear Security Administration. "While our people have
been concerned for years, and we have worked to be prepared, these events
have heightened our resolve."
Since 1999, researchers at Livermore and Los Alamos have worked to develop
a system capable of detecting airborne biological incidents for special
events, such as political conventions, dignitary visits and major sporting
events.
The system, called the Biological Aerosol Sentry and Information System,
or BASIS, has been developed under the Chemical and Biological National
Security Program of the National Nuclear Security Administration by Livermore
and Los Alamos scientists.
BASIS consists of a network of sampling units, similar to those used by
the Environmental Protection Agency to monitor air quality, to collect
and check aerosols. Filters capture aerosols and are then collected several
times a day for analysis.
At the heart of BASIS is a transportable field laboratory where collected
samples are analyzed using the most reliable and sensitive identification
techniques available. The samples are analyzed using DNA-based techniques
that have been validated by the Centers for Disease Control and Prevention.
BASIS reduces the time for detecting a bio-agent release from days or
weeks to less than a day, allowing public health officials to have much
more rapid warning, said Livermore project manager Dennis Imbro. "The
early notice could mean the difference between life and death for people
in any contaminated area," he said.
Public health procedures have traditionally relied on observation and
surveillance of symptoms displayed by infected individuals for detecting
and tracking outbreaks of disease such as those that might result from
a biological attack.
Wiley Davidson, Imbro’s fellow project leader at Los Alamos, emphasized
that the BASIS project is a partnership that includes public health and
law enforcement agencies.
"A strength of this program is that we work with the people on the
ground," Davidson said. "This allows feedback from responders
to flow back into the program and guide future research."
BASIS has undergone extensive, real-world testing in urban environments.
While no specific threats have been received for the Salt Lake City Olympic
Games, according to law enforcement officials, BASIS has been deployed
for use as part of the overall security for the event.
During preparations for the Olympic Games, Livermore and Los Alam,os researchers
worked closely with Utah Department of Health officials. "It’s
been a very good relationship," Imbro said.
In developing BASIS, Los Alamos scientists developed the system’s
aerosol collection units, the system’s command and control software
and sample handling procedures for outside the field laboratory.
For their part, Livermore scientists were responsible for the BASIS biodetection
equipment and DNA analysis procedures, as well as the system’s communications
capability.
About 30 Livermore biomedical researchers, computer scientists and engineers
have worked on the BASIS project during the past three years. At Los Alamos,
about 10 staffers have been involved in the project. This work builds
upon many years of research in the biological sciences at Los Alamos and
Livermore, including the well-known work on the Human Genome Project.
BASIS represents one system among a suite of bio-detection technologies
under development at LLNL. One instrument, the Handheld Advanced Nucleic
Acid Analyzer, or HANAA, is a portable machine that can be used to identify
pathogens based on their DNA, with results reported in about 30 minutes.
This technology is in the process of being licensed to Baltimore-based
Environmental Technologies Group, which expects to have commercial units
available this year.
A second instrument, an automated version of BASIS, is under development
and has been dubbed the Autonomous Pathogen Detection System. This is
a continuous and fully automated monitoring system that functions like
a biological smoke detector. It will be able to detect and identify as
many as 100 different types of potentially harmful organisms that may
be in the air. This systems is now in a prototype stage of development
and demonstration.
At Los Alamos, other technologies in development include the National
Infrastructure Simulation and Analysis Center, NISAC, a powerful new decision
support system for government and industry decision-makers in the areas
of crisis response, infrastructure policy, planning and investment. NISAC
uses the nation’s largest scientific computational capabilities to
discover previously unknown relationships and develop insights about infrastructure
vulnerabilities to feasible terrorist threats.
Las Alamos also has developed a new approach for neutralizing deadly toxins
released by pathogenic bacteria, such as those that cause anthrax and
plague. The researchers have designed and laboratory-tested a decoy molecule,
or receptor-mimicking molecule, that stops the spread of the bacteria’s
toxin by preferentially binding the toxin, thus keeping it from binding
to the immune system’s cells.