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Antibody Developability Scientist
Physical Life Sciences | livermore, CA | 05/12/2023
Job Code: SES.3 Science & Engineering MTS 3
Organization: Physical and Life Sciences
Position Type: Flexible Term
Security Clearance: None/Position does not require US citizenship (assignments longer than 179 days require a federal background investigation)
Drug Test: Required for external applicant(s) selected for this position (includes testing for use of marijuana)
Medical Exam: A job-related pre-placement medical examination may be required
Company Description
Join us and make YOUR mark on the World!
Are you interested in joining some of the brightest talent in the world to strengthen the United States’ security? Come join Lawrence Livermore National Laboratory (LLNL) where our employees apply their expertise to create solutions for BIG ideas that make our world a better place.
We are committed to a diverse and equitable workforce with an inclusive culture that values and celebrates the diversity of our people, talents, ideas, experiences, and perspectives. This is essential to innovation and creativity for continued success of the Laboratory’s mission.
Pay Range
$148,650.00 - $190,932.00 Annually
Please note that the pay range information is a general guideline only. Many factors are taken into consideration when setting starting pay including education, experience, the external labor market, and internal equity.
Job Description
We are seeking a highly motivated and experienced Antibody Developability Scientist to join our team focused on developing next-generation antibody therapeutics with optimized developability and pharmacokinetics. You will work closely with other members of the research team to design and engineer antibody candidates with improved properties, using state-of-the-art techniques and technologies. The role includes opportunities to pursue self-driven research and development in infectious disease and countermeasure design for future pandemic preparedness as part of the Biosciences and Biotechnology Division.
You will:
- Conduct assessments of antibody candidates and identify potential issues related to stability, aggregation, and other properties that may affect manufacturing and formulation.
- Proactively identify liabilities for antibody developability or pharmacokinetics and engineer mitigations using computational prediction tools, molecular biology, protein engineering, and other relevant techniques.
- Analyze and interpret data generated from traditional developability/PK studies and novel highthroughput proxy approaches to guide antibody design and optimization.
- Collaborate with our team of diverse expertise, including biochemists, infectious disease biologists, engineers, and computational biologists, to develop and optimize antibody screening and selection strategies.
- Contribute to and actively participate in the development of integrated research programs to meet sponsor needs in multiple national security focus areas. Interact with senior project staff and management to influence programmatic decisions.
- Interact with external collaborators and/or contract research organizations to explore and/or execute commercial complementation toward program goals.
- Develop new and innovative research approaches relevant to the needs of Laboratory programs and/or external funding agencies; write proposals, secure funding, and establish independent research projects.
- Prepare complex written analyses and verbal briefings and present research results at national and international conferences, technical meetings, periodic progress reports, and author scientific manuscripts.
- Perform other duties as assigned.
Qualifications
- PhD in Biochemistry, Molecular Biology, or a field related to Antibody or Biopharmaceutical Engineering or the equivalent combination of education and relevant experience.
- Demonstrated expertise in antibody engineering and protein design.
- Advanced knowledge of high throughput developability and/or pharmacokinetics/pharmacodynamics, including assessment and mitigation strategies.
- Ability to work collaboratively with researchers from diverse fields, including computational and experimental biologists, and provide scientific guidance, support, and leadership as needed.
- Advanced written, verbal communication and interpersonal skills necessary to deliver presentations, prepare written reports and to interact with a diverse set of scientists, engineers, and other technical and administrative staff.
Qualifications we desire:
- Broad familiarity with sequence- and structure-based protein modeling tools.
- Expertise in high throughput antibody production and screening platforms.
- Familiarity with cutting edge protein display platforms (e.g., yeast, phage, etc.) for high throughput data generation or evaluation of developability, affinity, specificity, and stability.
- Experience implementing and/or maintaining best practices for LIMS.
- Strong leadership, communication, and project management skills.
Additional Information
All your information will be kept confidential according to EEO guidelines.
Position Information
This is a Flexible Term appointment, which is for a definite period not to exceed six years. If final candidate is a Career Indefinite employee, Career Indefinite status may be maintained (should funding allow).
Why Lawrence Livermore National Laboratory?
- Flexible Benefits Package
- 401(k)
- Relocation Assistance
- Education Reimbursement Program
- Flexible schedules (*depending on project needs)
- Inclusion, Diversity, Equity and Accountability (IDEA) - visit https://www.llnl.gov/diversity
- Our core beliefs - visit https://www.llnl.gov/diversity/our-values
- Employee engagement - visit https://www.llnl.gov/diversity/employee-engagement
Security Clearance
None required. However, if your assignment is longer than 179 days cumulatively within a calendar year, you must go through the Personal Identity Verification process. This process includes completing an online background investigation form and receiving approval of the background check. (This process does not apply to foreign nationals.)
Pre-Employment Drug Test
External applicant(s) selected for this position must pass a post-offer, pre-employment drug test. This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor.
Pre-Placement Medical Exam
A job related pre-placement medical examination may be required.
Beware of Fraudulent Job Postings. LLNL’s hiring practices:
- Never requires job applicants to pay an application/training fee or submit personal documents like bank account details, passport number, Social Security number, tax forms or credit card information as part of the application process.
- For interviews and to be granted access to a Federal facility, a LLNL employee will contact you directly to collect visa, passport number, and/or Social Security number. To vet the authenticity of the employee please have them provide you their name and phone number and verify at people.llnl.gov.
- Involves at least one interview (virtual or in-person) and never interviews job applicants through chat platforms such as Google Hangouts, or via correspondence through text and instant messaging systems.
- Only sends email communications to job applicants from domain “@llnl.gov” or via their applicant tracking system, [email protected]. Occasionally LLNL uses third-party vendors that will contact you about job opportunities. If a recruiter contacts you to apply, you will always be directed to our career page to apply through our career site.
- Encourages all applicants to visit LLNL’s careers page at www.llnl.gov/join-our-team/careers if they saw the job posting on another site prior to applying to ensure the job posting is accurate and valid.
Equal Employment Opportunity
We are an equal opportunity employer that is committed to providing all with a work environment free of discrimination and harassment. All qualified applicants will receive consideration for employment without regard to race, color, religion, marital status, national origin, ancestry, sex, sexual orientation, gender identity, disability, medical condition, pregnancy, protected veteran status, age, citizenship, or any other characteristic protected by applicable laws.
We invite you to review the Equal Employment Opportunity posters which include EEO is the Law and Pay Transparency Nondiscrimination Provision.
Reasonable Accommodation
Our goal is to create an accessible and inclusive experience for all candidates applying and interviewing at the Laboratory. If you need a reasonable accommodation during the application or the recruiting process, please use our online form to submit a request.
California Privacy Notice
The California Consumer Privacy Act (CCPA) grants privacy rights to all California residents. The law also entitles job applicants, employees, and non-employee workers to be notified of what personal information LLNL collects and for what purpose. The Employee Privacy Notice can be accessed here.
