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Quantitative Metabolism - Postdoctoral Researcher

Entry Level | Full-time
Postdoctoral/Fellowship | livermore, CA | 03/04/2021

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Company Description

Join us and make YOUR mark on the World!

Are you interested in joining some of the brightest talent in the world to strengthen the United States’ security? Come join Lawrence Livermore National Laboratory (LLNL) where our employees apply their expertise to create solutions for BIG ideas that make our world a better place.

We are looking for individuals that demonstrate an understanding of working in partnership with team peers, who engage, advocate, and contribute to building an inclusive culture, and provide expertise to solve challenging problems.

Job Description

NOTE: This is a two-year Postdoctoral appointment with the possibility of extension to a maximum of three years.

The Biosciences and Biotechnology Division (BBTD) of the Physical and Life Sciences (PLS) Directorate at Lawrence Livermore National Laboratory is seeking a candidate for a postdoctoral researcher position in the area of quantitative metabolism. The research will focus on developing methods for the quantitation of metabolic products and pathways in biological systems using radio-labeled precursors measured by Accelerator Mass Spectrometry (AMS).  Postdoctoral Researchers at LLNL should expect to continue to receive training in performing independent research that is complementary to the work of other members of their department, while also participating in multidisciplinary projects.  The selected candidate will work with a dynamic interdisciplinary team of scientists and will report to the Human Health Sciences Group in the Biosciences and Biotechnology Division.

Essential Duties

  • Participate in the development and validation of new methods to quantify metabolites in biological systems using AMS- specifically coupling mass spectrometry analysis with AMS analysis for Parallel Accelerator Mass and Mass Spectrometry (PAMMS) analysis.
  • Conduct research on the biological mechanisms and metabolism in cellular systems, animal models or humans using radiolabeled substrates and accelerator mass spectrometry.
  • Administer carbon-14 labeled compounds to cell culture and animals; prepare samples for AMS analysis
  • Analyze samples for carbon-14 content using an Accelerator Mass Spectrometer
  • Organize, analyze, and present data from research at seminars, technical meetings, national and international conferences.
  • Publish research results in peer-reviewed scientific or technical journals.
  • Collaborate with others in a multidisciplinary team environment both at LLNL and in other national laboratories and universities to accomplish research goals.
  • Perform other duties as assigned.


  • PhD in Chemical Biology, pharmaceutical chemistry, Analytical chemistry, Biochemistry, or related field with emphasis on quantitative analytical measurements.
  • Experience using complex analytical instrumentation (such as LC-MS, LC-MS/MS, UPLC, GC-MS or IRMS) to understand cellular systems. 
  • Experience with analytical chemical methods for quantifying metabolites (such as quantitative isotope-dilution MS, isotope ratio MS, biomarker development).
  • Experience with method development using analytical instrumentation such as Mass Spectrometry.
  • Ability to understand and analyze data produced by quantitative analytical equipment.
  • Proficient verbal and written communication and interpersonal skills to collaborate effectively in a multidisciplinary team environment and present and explain technical information.

Desired Qualifications

  • Experience utilizing radioisotopes in biological research

Additional Information

Why Lawrence Livermore National Laboratory?

  • Included in 2020 Best Places to Work by Glassdoor!
  • Work for a premier innovative national Laboratory
  • Comprehensive Benefits Package
  • Flexible schedules (*depending on project needs)
  • Collaborative, creative, inclusive, and fun team environment

Learn more about our company, selection process, position types and security clearances by visiting our Career site

Security Clearance

LLNL is a Department of Energy (DOE) and National Nuclear Security Administration (NNSA) Laboratory.  Most positions will require a DOE L or Q clearance (please reference Security Clearance requirement).  If you are selected, we will initiate a Federal background investigation to determine if you meet eligibility requirements for access to classified information or matter. In addition, all L or Q cleared employees are subject to random drug testing.  An L or Q clearance requires U.S. citizenship.  If you hold multiple citizenships (U.S. and another country), you may be required to renounce your non-U.S. citizenship before a DOE L or Q clearance will be processed/granted.  For additional information please see DOE Order 472.2.

Equal Employment Opportunity

LLNL is an affirmative action and equal opportunity employer that values and hires a diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, religion, marital status, national origin, ancestry, sex, sexual orientation, gender identity, disability, medical condition, pregnancy, protected veteran status, age, citizenship, or any other characteristic protected by applicable laws.

If you need assistance and/or a reasonable accommodation during the application or the recruiting process, please submit a request via our online form

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The California Consumer Privacy Act (CCPA) grants privacy rights to all California residents. The law also entitles job applicants, employees, and non-employee workers to be notified of what personal information LLNL collects and for what purpose. The Employee Privacy Notice can be accessed here.

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