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Patents

Saccharide Sensing Molecules Having Enhanced Fluorescent Properties
Joe H. Satcher, Jr., Stephen M. Lane, Christopher B. Darrow, Douglas R. Cary, Joe Anh Tran
U.S. Patent 6,673,625 B2
January 6, 2004
This invention provides formulae for fluorescent compounds with properties that make them well suited for use in analyte sensors such as saccharides. These properties include favorable excitation and emission wavelengths and fluorescence lifetimes as well as photostability, enhanced aqueous solubility, and temperature and pH sensitivity. The compound has an aryl or a substituted phenyl botonic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. The fluorescent compounds are excited at wavelengths greater than 400 nanometers and emit at wavelengths greater than 450 nanometers, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal–ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as from anthracene compounds. The fluorescent compound can be immobilized in a glucose-permeable biocompatible polymer matrix and implanted under the skin.

Parallel Object-Oriented Data Mining System
Chandrika Kamath, Erick Cantu-Paz
U.S. Patent 6,675,164 B2
January 6, 2004
A data mining system uncovers patterns, association, anomalies, and other statistically significant structures in data. When data files are read and displayed, objects in the files are identified, and relevant features of the objects are extracted. Patterns among the objects are recognized based on the features. Data from the Faint Images of the Radio Sky at Twenty Centimeters (FIRST) sky survey were used to search for bent doubles. This test was conducted on data from the Very Large Array in New Mexico, which seeks to locate a special type of quasar—a radio-emitting stellar object—called bent doubles. The FIRST survey has generated more than 32,000 images of the sky to date. Each image is 7.1 megabytes, yielding more than 100 gigabytes of image data in the entire data set.

Manifold Free Multiple Sheet Superplastic Forming
John W. Elmer, Robert L. Bridges
U.S. Patent 6,677,011 B2
January 13, 2004
Fluid-forming compositions in a container attached to enclosed adjacent sheets are heated to relatively high temperatures to generate fluids (gases) that inflate the sheets. Fluid rates to the enclosed space between the sheets can be regulated by the canal from the container. Inflated articles can be produced by a continuous, rather than batch-type process.

Thin Film Transistors on Plastic Substrates
Paul G. Carey, Patrick M. Smith, Thomas W. Sigmon, Randy C. Aceves
U.S. Patent 6,680,485 B1
January 20, 2004
A process for forming thin-film transistors (TFTs) on plastic substrates, which replaces standard TFT fabrication techniques, uses sufficiently lower processing temperatures so that inexpensive plastic substrates may be used in place of standard glass, quartz, and silicon wafer–based substrates. The silicon-based TFT produced by the process includes a low-temperature substrate that cannot withstand sustained processing temperatures greater than about 250°C; an insulating layer on the substrate; a layer of silicon on the insulating layer that has sections of doped silicon, undoped silicon, and polysilicon; a gate dielectric layer on the layer of silicon; a layer of gate metal on the dielectric layer; a layer of oxide on sections of the silicon layer and the gate-metal layer; and metal contacts on sections of the silicon and gate-metal layers to define source, gate, and drain contacts as well as interconnects.

Single-Fiber Multi-Color Pyrometry
Ward Small IV, Peter Celliers
U.S. Patent 6,682,216 B1
January 27, 2004
This invention is a fiber-based multicolor pyrometry set up for real-time noncontact temperature and emissivity measurement. The system includes a single optical fiber to collect radiation emitted by a target; a reflective rotating chopper to split the collected radiation into two or more paths while modulating the radiation for lock-in amplification; at least two detectors, possibly of different spectral bandwidths, with or without filters to limit the wavelength regions detected; and optics to direct and focus the radiation onto the sensitive areas of the detectors. A computer algorithm is used to calculate a target’s true temperature and emissivity based on blackbody calibrations. The system components are enclosed in a light-tight housing, with a fiber extending outside to collect the radiation. Radiation emitted by the target is transmitted through the fiber to the reflective chopper, which either allows the radiation to pass straight through or reflects the radiation into one or more paths. Each path includes a detector with or without filters and corresponding optics to direct and focus the radiation onto the active area of the detector. The signals are recovered using lock-in amplification. Calibration formulas for the signals obtained using a blackbody of known temperature are used to compute the target’s true temperature and emissivity. The temperature range of the pyrometer system is determined by the spectral characteristics of the optical components.

Glucose Sensing Molecules Having Selected Fluorescent Properties
Joe H. Satcher, Jr., Stephen M. Lane, Christopher B. Darrow, Douglas R. Cary, Joe Anh Tran
U.S. Patent 6,682,938 B1
January 27, 2004
An analyte-sensing fluorescent molecule that uses intramolecular electron transfer is designed to exhibit selected fluorescent properties in the presence of analytes such as saccharides. The selected fluorescent properties include excitation wavelength, emission wavelength, fluorescence lifetime, quantum yield, photostability, solubility, and temperature or pH sensitivity. The compound has an aryl or a substituted phenyl boronic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. The fluorophore and switch component are selected so that the free energy for electron transfer is less than about 3.0 kilocalories per mole. Fluorescent compounds are excited at wavelengths greater than 400 nanometers and emit at wavelengths greater than 450 nanometers, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal–ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as from anthracene compounds. The fluorescent compound can be immobilized in a glucose-permeable biocompatible polymer matrix and implanted under the skin.

Movement of Particles Using Sequentially Activated Dielectrophoretic Particle Trapping
Robin R. Miles
U.S. Patent 6,685,812 B2
February 3, 2004
Manipulation of DNA and cells or spores using dielectrophoretic (DEP) forces to prepare samples for polymerized chain reaction– (PCR-) based assays for various applications. This manipulation is accomplished by moving particles using sequentially activated DEP particle trapping. DEP forces induce a dipole in particles, so the particles can be trapped in nonuniform fields. The particles can be trapped in the high-field-strength region of one set of electrodes. By switching off this field and switching on an adjacent electrode, particles can be moved down a channel with little or no flow.

Highly-Basic Large-Pore Zeolite Catalysts for NOx Reduction at Low Temperatures
Bernardino M. Penetrante, Raymond M. Brusasco, Bernard T. Merritt, George E. Vogtlin
U.S. Patent 6,685,897 B1
February 3, 2004
A high-surface-area (greater than 600 square meters per gram), large-pore (diameter greater than 0.65 nanometer), basic zeolite with an alkali metal cation-exchanged Y-zeolite structure is used to convert NOx contained in an oxygen-rich engine exhaust to N2 and O2. Preferably, the invention relates to a two-stage method and apparatus for NOx reduction in an oxygen-rich engine exhaust, such as diesel engine exhaust, that includes a plasma oxidative stage and a selective reduction stage. The first stage uses a nonthermal plasma treatment of NOx gases in an oxygen-rich exhaust and is intended to convert NO to NO2 in the presence of O2 and added hydrocarbons. The second stage uses a lean-NOx catalyst including the basic zeolite at relatively low temperatures to convert the NO2 to environmentally benign gases such as N2, CO2, and H2O.

Aerosol Sampling System
Donald A. Masquelier
U.S. Patent 6,688,187 B1
February 10, 2004
A system for sampling air and collecting particulate of a predetermined range of particle sizes. A low-pass section has an opening that is sized to gather the air but exclude particles larger than the sample particles. An impactor section connected to the low-pass section separates the air flow into either a bypass air flow, which does not contain the sample particles, or a product air flow, which does contain the sample particles. A wetted-wall cyclone collector, connected to the impactor section, receives the product air flow and traps the sample particles in a liquid.

Awards



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UCRL-52000-04-5 | May 7, 2004