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  FOR IMMEDIATE RELEASE
June 25, 2001
NR-01-06-04

NEW DISCOVERIES IN THE PROCESS OF BONE, SHELL GROWTH

New research on the process biological organisms use to modify crystal shape and growth, forming such complex structures as bones, eggshells and seashells, is detailed in the most recent issue of the science journal, Nature.

Christine Orme of Lawrence Livermore National Laboratory is the lead author of the article, titled "Formation of Chiral Morphologies through Selective Binding of Amino Acids to Calcite Surface Steps." It details the research and discoveries of a team of physicists, chemists and geologists from Livermore, in collaboration with the University of South Alabama and Virginia Polytechnic.

The results of the team's research will apply in myriad uses, from potential laboratory growth of human and animal bones to industrial scale formation in pipes to the manufacture of toothpaste — any situation in which calcium-based crystals grow naturally or are utilized.

Orme explains that calcite, the material in eggshells and seashells, is the perfect model system for studying "biomineralization," the organic growth of crystalline structures.

"Pure calcite grows only in a symmetrical, six-sided pyramid-shaped crystal," said Orme. "We've wondered how nature controls the growth of the same substance into the intricate shapes found in shells and sea urchin spines. Now, by binding it with the amino acid aspartate, which is a common amino acid found in the protein of shellfish, we've been able to skew the growth to form asymmetric crystals, which are mirror-images of one another depending on whether we use right or left-handed amino acids."

The results were seen quite clearly through the Lab's atomic-level microscopes, in which the team could measure the atomic-step speed and other variables in crystal growth. Surface spectroscopy and molecular modeling confirmed the visual results.

"The exciting outcome," said Orme, "is creating a picture of how these shape changes, on the molecular scale, guide the growth of a crystal into its ultimate form."

Furthermore, Orme reported the geophysical community has responded with great enthusiasm, citing the study results as a means of differentiating between carbonate crystals of biological and non-biological origin, based on the presence or absence of the aspartate.

Also, this discovery may prove a "geochronological tool" to date fossils.

Finally, Orme said, the results reflect on the origin of life itself. "They support the hypothesis that mineral surfaces (such as calcite) were responsible for the emergence of a single chiral form of the amino acids found in living organisms."

The term "chiral" in the title refers to mirror-image molecules, otherwise identical in sturcture, therefore "left" or "right" facing.

The team is now moving on to research involving calcium phosphate, the material used by animals to grow bones. If ever bones are to be grown in the laboratory, these are the first steps in that process, said Orme.

Other team members participating in this research were Aleksandr Noy, Mary McBride and James de Yoreo of LLNL; Andrzej Wierzbicki, University of South Alabama; Meg Grantham and Patricia Dove, Virginia Polytechnic Institute and Henry Teng, George Washington University.

For the complete article, see the June 14 issue of Nature which has both the article as well as a News and Views summary of the research.


Founded in 1952, Lawrence Livermore National Laboratory is a national security laboratory that develops science and engineering technology and provides innovative solutions to our nation's most important challenges. Lawrence Livermore National Laboratory is managed by Lawrence Livermore National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration.