High Throughput Protein Display Platform Scientist
Physical Life Sciences | livermore, CA | 08/15/2023
Job Code: SES.3 Science & Engineering MTS 3
Organization: Physical and Life Sciences
Position Type: Flexible Term
Security Clearance: None/Position does not require US citizenship (assignments longer than 179 days require a federal background investigation)
Drug Test: Required for external applicant(s) selected for this position (includes testing for use of marijuana)
Medical Exam: A job-related pre-placement medical examination may be required
Join us and make YOUR mark on the World!
Are you interested in joining some of the brightest talent in the world to strengthen the United States’ security? Come join Lawrence Livermore National Laboratory (LLNL) where our employees apply their expertise to create solutions for BIG ideas that make our world a better place.
We are committed to a diverse and equitable workforce with an inclusive culture that values and celebrates the diversity of our people, talents, ideas, experiences, and perspectives. This is essential to innovation and creativity for continued success of the Laboratory’s mission.
$153,210 - $196,788 Annually
Please note that the pay range information is a general guideline only. Many factors are taken into consideration when setting starting pay including education, experience, the external labor market, and internal equity.
We are seeking a highly motivated and experienced Staff Scientist to join our team as a High Throughput Protein Display Platform Scientist. Our ideal candidate will have a strong background in protein engineering, display technologies (cell-based, phage-based, and/or cell-free), and the design and assembly of large variant libraries. If you are a self-motivated individual who thrives in a dynamic and fast-paced environment, and who is passionate about using display technologies to discover and optimize new proteins, we encourage you to apply. This position is in the Biosciences and Biotechnology Division.
- Develop and optimize high throughput protein display platforms to identify and optimize new proteins with desired properties.
- Design and construct libraries for display-based selection methods.
- Ideate and reduce to practice innovative approaches to massively parallel characterization of many antibody variants in parallel through novel adaptations of conventional library screening methods.
- Characterize protein-ligand interactions and screen protein libraries to identify and select high affinity binders.
- Work collaboratively with other scientists and research teams to integrate and apply display technologies to enhance drug discovery efforts.
- Document experimental data and results, and present findings to internal teams and external partners.
- Participate in preparing for annual safety inspections and maintaining a safe laboratory environment in collaboration with EH&S.
- Perform other duties as assigned.
- PhD in molecular biology, biochemistry, genetics, synthetic biology, or a related field or equivalent combination of education and relevant experience.
- Demonstrated expertise in display technologies (e.g., phage display, yeast display, bacterial display).
- Significant experience with design and/or assembly of large variant libraries (i.e. >106 variants).
- Advanced knowledge of protein engineering and biochemistry.
- Significant experience with protein-ligand interactions and screening assays.
- Familiarity with NGS-based approaches for variant library characterization.
- Ability to work collaboratively with researchers from diverse fields, including computational and experimental biologists, and provide scientific guidance, support, and leadership as needed.
- Advanced written, verbal communication and interpersonal skills necessary to deliver presentations, prepare written reports and to interact with a diverse set of scientists, engineers, and other technical and administrative staff.
Qualifications We Desire
- Experience with high-throughput methods and automation.
- Proficiency with modern methods of multi-component DNA assembly and cloning.
- Ability to distill esoteric and complex concepts for productive communication with vendors, sponsors, community members, and other stakeholders.
- Working knowledge of various in vivo and in vitro methods commonly used to screen large variant libraries.
- Experience developing and screening antibody display libraries.
- Experience designing, executing, and analyzing high-out NGS-based experiments on both short-read and long-read platforms.
- Strong leadership, communication, and project management skills.
All your information will be kept confidential according to EEO guidelines.
This is a Flexible Term appointment, which is for a definite period not to exceed six years. If final candidate is a Career Indefinite employee, Career Indefinite status may be maintained (should funding allow).
Why Lawrence Livermore National Laboratory?
- Flexible Benefits Package
- Relocation Assistance
- Education Reimbursement Program
- Flexible schedules (*depending on project needs)
- Inclusion, Diversity, Equity and Accountability (IDEA) - visit https://www.llnl.gov/diversity
- Our core beliefs - visit https://www.llnl.gov/diversity/our-values
- Employee engagement - visit https://www.llnl.gov/diversity/employee-engagement
None required. However, if your assignment is longer than 179 days cumulatively within a calendar year, you must go through the Personal Identity Verification process. This process includes completing an online background investigation form and receiving approval of the background check. (This process does not apply to foreign nationals.)
Pre-Employment Drug Test
External applicant(s) selected for this position must pass a post-offer, pre-employment drug test. This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor.
Pre-Placement Medical Exam
A job related pre-placement medical examination may be required.
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