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Computational Chemist - Postdoctoral Researcher
Physical Life Sciences | livermore, CA | 05/11/2023
Job Code: PDS.1 Post-Dr Research Staff 1
Organization: Physical and Life Sciences
Position Type: Post Doctoral
Security Clearance: None/Position does not require US citizenship (assignments longer than 179 days require a federal background investigation)
Drug Test: Required for external applicant(s) selected for this position (includes testing for use of marijuana)
Medical Exam: A job-related pre-placement medical examination may be required
Company Description
Join us and make YOUR mark on the World!
Are you interested in joining some of the brightest talent in the world to strengthen the United States’ security? Come join Lawrence Livermore National Laboratory (LLNL) where our employees apply their expertise to create solutions for BIG ideas that make our world a better place.
We are committed to a diverse and equitable workforce with an inclusive culture that values and celebrates the diversity of our people, talents, ideas, experiences, and perspectives. This is essential to innovation and creativity for continued success of the Laboratory’s mission.
Pay Range:
$108,840 Annually
Please note that the pay range information is a general guideline only. Many factors are taken into consideration when setting starting pay including education, experience, the external labor market, and internal equity.
Job Description
NOTE: This is a two-year Postdoctoral appointment with the possibility of extension to a maximum of three years.
We have an opening for a highly motivated Postdoctoral Researcher to conduct research in enzyme catalysis and small molecule drug discovery with expertise in molecular modeling and simulations of biological systems, free energy calculations, and quantum mechanical calculations. You will be an integral member of an interdisciplinary team working with computational chemists, and experimental chemists and biologists. You will be responsible for investigating the mechanism of brain proteins and searching for hit compounds or designing compounds to inhibit/promote function. You will present your work regularly and publish your research and findings, which includes occasional domestic travel. This position is in the Biochemical and Biophysical Systems group of the Biosciences and Biotechnology Division.
You will
- Conduct advanced independent research to investigate the mechanism of brain proteins and design small molecule to inhibit/promote function.
- Perform and automate high throughput molecular dynamics simulations and free energy calculations to predict small molecular binding.
- Develop new analytics to analyze results from complex biology experiments and simulations.
- Work with external partners (Universities, Industry, other National Laboratories) to advance computational biology simulation efforts.
- Prepare complex and detailed weekly progress reports to support project needs and deadlines. Prepare complex written analyses and verbal briefings, and present research results to sponsors.
- Develop new and innovative research methods relevant to the needs of Laboratory programs and/or external funding agencies.
- Contribute to proposals and statements of work.
- Publish research results in peer-reviewed scientific or technical journals and present results at external conferences, seminars and/or technical meetings, which requires travel.
- Perform other duties as assigned.
Qualifications
- PhD in computational biology, computational physics, computer science, or computational chemistry.
- Knowledge and significant experience in protein function prediction, protein-ligand binding, molecular dynamics simulations, and free energy calculations.
- Experience in quantum mechanical calculation, hybrid quantum mechanics/ molecular mechanics (QM/MM) simulations, and enzyme catalysis
- Ability to work independently on defined research projects, as well as a member of a team with a diverse set of scientists, engineers, and other technical and administrative staff.
- Computer skills including programming experience with perl, python, or C++, preferably in a UNIX environment.
- Ability to develop independent research projects as demonstrated through publication of peer-reviewed manuscripts.
- Ability to travel, as necessary, to interact with collaborators.
Qualifications We Desire
- Experience in machine learning.
- Experience in collaborating with experimental biologists.
- Experience in automated analysis and data visualization.
Additional Information
All your information will be kept confidential according to EEO guidelines.
Position Information
This is a Postdoctoral appointment with the possibility of extension to a maximum of three years, open to those who have been awarded a PhD at time of hire date.
Why Lawrence Livermore National Laboratory?
- Flexible Benefits Package
- 401(k)
- Relocation Assistance
- Education Reimbursement Program
- Flexible schedules (*depending on project needs)
- Inclusion, Diversity, Equity and Accountability (IDEA) - visit https://www.llnl.gov/diversity
- Our core beliefs - visit https://www.llnl.gov/diversity/our-values
- Employee engagement - visit https://www.llnl.gov/diversity/employee-engagement
Security Clearance
None required. However, if your assignment is longer than 179 days cumulatively within a calendar year, you must go through the Personal Identity Verification process. This process includes completing an online background investigation form and receiving approval of the background check. (This process does not apply to foreign nationals.)
Pre-Employment Drug Test
External applicant(s) selected for this position must pass a post-offer, pre-employment drug test. This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor.
Pre-Placement Medical Exam
A job related pre-placement medical examination may be required.
Beware of Fraudulent Job Postings. LLNL’s hiring practices:
- Never requires job applicants to pay an application/training fee or submit personal documents like bank account details, passport number, Social Security number, tax forms or credit card information as part of the application process.
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- Encourages all applicants to visit LLNL’s careers page at www.llnl.gov/join-our-team/careers if they saw the job posting on another site prior to applying to ensure the job posting is accurate and valid.
Equal Employment Opportunity
We are an equal opportunity employer that is committed to providing all with a work environment free of discrimination and harassment. All qualified applicants will receive consideration for employment without regard to race, color, religion, marital status, national origin, ancestry, sex, sexual orientation, gender identity, disability, medical condition, pregnancy, protected veteran status, age, citizenship, or any other characteristic protected by applicable laws.
We invite you to review the Equal Employment Opportunity posters which include EEO is the Law and Pay Transparency Nondiscrimination Provision.
Reasonable Accommodation
Our goal is to create an accessible and inclusive experience for all candidates applying and interviewing at the Laboratory. If you need a reasonable accommodation during the application or the recruiting process, please use our online form to submit a request.
California Privacy Notice
The California Consumer Privacy Act (CCPA) grants privacy rights to all California residents. The law also entitles job applicants, employees, and non-employee workers to be notified of what personal information LLNL collects and for what purpose. The Employee Privacy Notice can be accessed here.
