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Academic Graduate Appointee - Histopathology Technician

Entry Level | Full-time
Physical Life Sciences | livermore, CA | 03/15/2023

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Company Description

Join us and make YOUR mark on the World!

Are you interested in joining some of the brightest talent in the world to strengthen the United States’ security? Come join Lawrence Livermore National Laboratory (LLNL) where our employees apply their expertise to create solutions for BIG ideas that make our world a better place.

We are committed to a diverse and equitable workforce with an inclusive culture that values and celebrates the diversity of our people, talents, ideas, experiences, and perspectives. This is essential to innovation and creativity for continued success of the Laboratory’s mission.

Pay Range: 

$5,380 to $7,372 Monthly.  

Please note that the pay range information is a general guideline only.  Many factors are taken into consideration when setting starting pay including education, experience, the external labor market, and internal equity.

Job Description

NOTE:  This is a one-year Academic Graduate Appointee with the possibility of extension to a maximum of two years. For important information about LLNL appointments refer to the FAQs above.

We have an opening for an Academic Graduate Appointee to participate in biomedical research conducting histopathology, immunohistochemistry on tissue sections, cell culture, cell sorting of homogenized tissues and single-cell RNA preparations. You will work in a highly integrated environment as part of a multi-disciplinary team to develop, optimize, characterize, and validate methods for assessing protein and gene expression in the context of several models of human diseases such as cancer and pneumonia.  The work combines basic techniques in histology (tissue harvesting and microdisection, fixation, dehydration, sectioning, staining, and imaging) and cell culture (in vitro culture, passaging, and cell-based assays), ensuring tissue and cytology specimens are properly processed for histopathology, immunohistochemistry, spatial transcriptomics, or cytometric analysis. This position is in the Biosciences and Biotechnology Division, Human Health Sciences Group.               

In this role you will:

  • Assist with tissue collection, fixation and embedding. Develop protocols and procedures for tissues (lung, brain, etc) using different fixation techniques (paraffin and OCT).
  • Generate tissue sections by operating microtome, cryotome, and/or vibrotome, depending on tissue type and analyses required by active projects.
  • Stain sectioned tissue with various histological stains (Safranin O, Trichrome, H&E), image tissue, annotate images with relevant information.
  • Optimize antibody selection for use in immunohistochemical (IHC) staining of fixed and sectioned tissues. Conduct IHCs and image protein expression. Troubleshoot initial results and optimize multi-color imaging to visualize 2-3 different proteins in the same tissue section.
  • Optimize and prepare tissue sections for spatial transcriptomics
  • Optimize tissue digests for single cell sequencing or flow cytommetry
  • Culture heterogenous cell populations
  • Maintain an accurate and detailed laboratory journal.
  • Ensure all experiments are performed within ES&H safety guidelines and that waste from all experiments is characterized and disposed of properly.
  • Collaborate with LLNL engineering staff and other offsite institutions on projects in biomaterials, 3D bioprinting and advanced ex vivo systems research.”
  • Occasional weekend work and/or additional hours during the week may be required to follow through on ongoing experiments.
  • Perform other duties as assigned.


  • B.S. in Molecular and Cell Biology, Anatomy, Physiology, Genetics or related field.
  • Experience with or working knowledge of antibody based immunological assays, including ELISA, FACS, immunohistochemistry, etc.
  • Knowledge of typical cell and molecular biology laboratory instruments.
  • Proficient interpersonal, verbal, and written communication skills necessary to effectively collaborate in a team environment with a diverse technical staff.
  • Ability to multi-task with a team on multiple time constrained projects.
  • Ability to follow standard laboratory protocols and ES&H safety procedures.
  • Experience using personal computers, Excel and PowerPoint applications.
  • Analytical, record-keeping and organizational skills necessary for working in a laboratory environment.

Qualifications we desire:

  • Experience with tissue harvesting and fixation, immunohistochemistry techniques, imaging and image processing.
  • Experience with a broad range of molecular biological techniques and ability to adapt and troubleshoot new methods for difficult samples.
  • Experience working with extracellular matrices and embedding of cells in scaffold.

Additional Information

All your information will be kept confidential according to EEO guidelines.

Position Information

This is a one-year Academic Graduate Appointee, open to those who have been awarded a degree at the time of the employment offer.

Why Lawrence Livermore National Laboratory?

Security Clearance

None required.  However, if your assignment is longer than 179 days cumulatively within a calendar year, you must go through the Personal Identity Verification process.  This process includes completing an online background investigation form and receiving approval of the background check.  (This process does not apply to foreign nationals.) 

Pre-Employment Drug Test

External applicant(s) selected for this position must pass a post-offer, pre-employment drug test. This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor.

Pre-Placement Medical Exam

A job related pre-placement medical examination may be required.

Equal Employment Opportunity

We are an equal opportunity employer that is committed to providing all with a work environment free of discrimination and harassment. All qualified applicants will receive consideration for employment without regard to race, color, religion, marital status, national origin, ancestry, sex, sexual orientation, gender identity, disability, medical condition, pregnancy, protected veteran status, age, citizenship, or any other characteristic protected by applicable laws.

We invite you to review the Equal Employment Opportunity posters which include EEO is the Law and Pay Transparency Nondiscrimination Provision.

Reasonable Accommodation

Our goal is to create an accessible and inclusive experience for all candidates applying and interviewing at the Laboratory.  If you need a reasonable accommodation during the application or the recruiting process, please use our online form to submit a request. 

California Privacy Notice

The California Consumer Privacy Act (CCPA) grants privacy rights to all California residents. The law also entitles job applicants, employees, and non-employee workers to be notified of what personal information LLNL collects and for what purpose. The Employee Privacy Notice can be accessed here.

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