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Academic Graduate Appointee - Translational Immunology

Entry Level | Full-time
Physical Life Sciences | livermore, CA | 10/27/2021

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Company Description

Join us and make YOUR mark on the World!

Are you interested in joining some of the brightest talent in the world to strengthen the United States’ security? Come join Lawrence Livermore National Laboratory (LLNL) where our employees apply their expertise to create solutions for BIG ideas that make our world a better place.

We are committed to a diverse and equitable workforce with an inclusive culture that values and celebrates the diversity of our people, talents, ideas, experiences, and perspectives. This is essential to innovation and creativity for continued success of the Laboratory’s mission.

Job Description

NOTE:  This is a one-year Academic Graduate Appointee with the possibility of extension to a maximum of two years. For important information about LLNL appointments refer to the FAQs above.

We have an opening for an Academic Graduate Appointee participating in developing novel approaches for synthetic vaccine development and characterizing interactions between microorganisms grown for bioenergy applications.  The candidate will work in a highly integrated environment as part of a multi-disciplinary team to develop, optimize, characterize, and validate methods for the production and characterization of proteins and nucleic acid-based vaccine development.  This position is in the Biology and Biotechnology Division, Pharmacology and Toxicology Group and the Microbiology and Immunology Group. Position reports to the project manager/Principal Investigator (PI).

In this role you will:

  • Design, perform and analyze cell-free expression experiments to test, and develop protocols and procedures to produce novel membrane bound proteins and analyze immunological experiments to quantify impacts of vaccination innate and cell mediated immunity.
  • Contribute to and carry out the design of experiments involving molecular biology techniques including biochemical tests using immunoassay techniques to characterize proteins of interest. 
  • Troubleshoot initial results and perform protein assay development using molecular biological techniques as needed.
  • Application and design of PCR assays to monitor biological pathways in cells and animals.
  • Image microbial cultures using light microscopy and learn image analysis workflows
  • Keep an accurate and detailed laboratory notebook and maintain complete records of experiments and contribute to general lab maintenance.
  • Perform all assignments in accordance with ES&H, security, and business practice requirements and policies.
  • Perform other duties as assigned.


  • B.S. in biological or physical science or equivalent course work
  • Experience working with gel electrophoresis.
  • Experience with or working knowledge of antibody based immunological assays, including ELISA, FACS, etc.
  • Knowledge of typical molecular biology laboratory instruments.
  • Interpersonal and communication skills to effectively work in a team environment with a diverse technical staff.
  • Ability to multi-task with a team on multiple time constrained projects.
  • Ability to follow standard laboratory protocols and ES&H safety procedures.
  • Experience using personal computers, Excel and Powerpoint applications.
  • Analytical, record-keeping and organizational skills necessary for working in a laboratory environment.
  • Interest in cultivation, characterization, imaging, and image analyses of microorganisms.

Qualifications we desire:

  • Experience with DNA extraction using Qiagen kits including minipreps, maxipreps, gel extraction, and PCR purification. 
  • Western blotting, ELISA based assays, multi-color flow cytometry, molecular cloning using restriction enzymes, plasmids, and bacteria
  • Understanding of and comfort with the use of PCR amplification, bioinformatic databases and Web based tools.
  • Experience working with proteins and aseptic technique.

Additional Information

Why Lawrence Livermore National Laboratory?

  • Included in 2020 Best Places to Work by Glassdoor!
  • Work for a premier innovative national Laboratory
  • Comprehensive Benefits Package
  • Flexible schedules (*depending on project needs)
  • Collaborative, creative, inclusive, and fun team environment

Learn more about our company, selection process, position types and security clearances by visiting our Career site

COVID-19 Vaccination Mandate

LLNL demonstrates its commitment to public safety by requiring that all new Laboratory employees be immunized against COVID-19 unless granted an accommodation under applicable state or federal law. This requirement will apply to all new hires including those who will be working on site, as well as those who will be teleworking.

Security Clearance

LLNL is a Department of Energy (DOE) and National Nuclear Security Administration (NNSA) Laboratory.  Most positions will require a DOE L or Q clearance (please reference Security Clearance requirement).  If you are selected, we will initiate a Federal background investigation to determine if you meet eligibility requirements for access to classified information or matter. In addition, all L or Q cleared employees are subject to random drug testing.  An L or Q clearance requires U.S. citizenship.  If you hold multiple citizenships (U.S. and another country), you may be required to renounce your non-U.S. citizenship before a DOE L or Q clearance will be processed/granted.  For additional information please see DOE Order 472.2.

Equal Employment Opportunity

LLNL is an affirmative action and equal opportunity employer that values and hires a diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, religion, marital status, national origin, ancestry, sex, sexual orientation, gender identity, disability, medical condition, pregnancy, protected veteran status, age, citizenship, or any other characteristic protected by applicable laws.

LLNS is committed to offering reasonable accommodations during the application and recruiting processes due to a disability.  If you need assistance or an accommodation due to a disability, please submit a request via our online form

California Privacy Notice

The California Consumer Privacy Act (CCPA) grants privacy rights to all California residents. The law also entitles job applicants, employees, and non-employee workers to be notified of what personal information LLNL collects and for what purpose. The Employee Privacy Notice can be accessed here.

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